Prof. Dr. Amparo Acker-Palmer

Professor for Molecular and Cellular Neurobiology, Goethe-University Frankfurt, Buchmann Institute for Molecular Life Sciences (BMLS) and Institute for Biophysics, Goethe-University, Frankfurt am Main

Max-Planck Fellow, MPI for Brain Research, Frankfurt


Research Positions

Max-Planck Independent Junior Research Group Leader, MPI of Neurobiology, Martinsried, Germany


Honors and Awards

PhD Extraordinary Award University of Valencia

Member of the German National Academy of Sciences Leopoldina

Deputy-Speaker SFB 1080 „Molecular and cellular mechanisms of neuronal homeostasis” (Mainz/Frankfurt)

EMBO member

Speaker SFB 1080 „Molecular and cellular mechanisms of neuronal homeostasis” (Mainz/Frankfurt)

ERC Advanced Grant Awardee


Selected papers

1. Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system. Segarra M, Aburto MR, Cop F, Llaó-Cid C, Härtl R, Damm M, Bethani I, Parrilla M, Husainie D, Schänzer A, Schlierbach H, Acker T, Mohr L, Torres-Masjoan L, Ritter M, Acker-Palmer A. Science 2018, 361:6404

2. GRIP1 regulates ApoER2/ephrinB2 functions at the synapse. Pfennig S#, Foss F#, Bissen D,  Harde E, Treeck J, Segarra M and Acker-Palmer A. Cell Reports 2017, 21:84-96.

3. EphrinB2 repression mediates tumor invasion and evasive resistance to anti-angiogenesis. Depner C, Zum Buttel H, Bö?ürcü N, Cuesta AM, Aburto MR, Seidel S, Finkelmeier F, Foss F, Hofmann J, Kaulich K, Barbus S, Segarra M, Reifenberger G, Garvalov BK, Acker T,* Acker-Palmer A*. Nature Communications 2016, 7:12329 *equal contribution.

4. Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR. Henze AT, Garvalov BK, Seidel S, Cuesta A, Ritter M, Filatova A, Foss F, Dopeso H, Essmann CL, Maxwell PH, Reifenberger G, Carmeliet P, Acker-Palmer A*, Acker T*. Nature Communications 2014, 5:5582 *equal contribution.

5. PHD3 regulates EGFR internalization and signaling in tumours. Garvalov BK*, Foss F*, Henze, AT, Bethani I, Gräf-Höchst S, Singh D, Filatova A, Dopeso H, Seidel S, Damm M, Acker-Palmer A*, Acker T*. Nature Communications 2014, 5:5577 *equal contribution.

6. The GRIP1/14-3-3 pathway coordinates cargo trafficking and dendrite development. Geiger JC, Lipka J, Segura I, Hoyer S, Schlager MA, Wulf PS, Weinges S, Demmers J, Hoogenraad CC, Acker-Palmer A. Developmental Cell 2014, 28:381-393.

7. EphrinBs are essential components of the Reelin pathway to regulate neuronal migration. Senturk A., Pfennig S, Weiss A, Burk K, Acker-Palmer, A. Nature 2011, 472:356-60 (Erratum 478:274).

8. EphrinB2 regulates VEGFR2 function in developmental and tumour angiogenesis. Sawamiphak S, Seidel S, Essmann CL, Wilkinson G, Pitulescu ME, Acker T, Acker-Palmer A. Nature 2010, 465:487-491.

9. Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors. Essmann CL, Martinez E, Geiger J, Zimmer M, Traut M,Stein V, Klein R, Acker-Palmer A. Nature Neuroscience 2008, 11:1035–1043.

10. Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Segura I, Essmann CL, Weinges S, Acker-Palmer A. Nature Neuroscience 2007, 10:301-310.