• Learning-induced biases in the ongoing dynamics of sensory representations predict stimulus generalization. Aschauer DF, Eppler JB, Ewig L, Chambers AR, Pokorny C, Kaschube M, Rumpel S. Cell Reports 2022, 38, http://dx.doi.org/10.1016/j.celrep.2022.110340
• Modulation of working memory duration by synaptic and astrocytic mechanisms. Becker S, Nold A, Tchumatchenko T. PLoS Computational Biology 2022, 18, e1010543. http://dx.doi.org/10.1371/journal.pcbi.1010543
• Expansion microscopy of mouse brain organotypic slice cultures to study protein distribution. Bissen D, Kracht MK, Foss F, Acker-Palmer A. STAR Protocols 2022, 3, 101507. http://dx.doi.org/https://doi.org/10.1016/j.xpro.2022.101507
• A stable sensory map emerges from a dynamic equilibrium of neurons with unstable tuning properties. Chambers AR, Aschauer DF, Eppler J-B, Kaschube M, Rumpel S. Cerebral Cortex 2022, http://dx.doi.org/10.1093/cercor/bhac445
• Mean curvature motion facilitates the segmentation and surface visualization of electron tomograms. Frangakis AS. Journal of Structural Biology 2022, 214, 107833. http://dx.doi.org/https://doi.org/10.1016/j.jsb.2022.107833
• SEDDS-loaded mucoadhesive fiber patches for advanced oromucosal delivery of poorly soluble drugs. Friedl JD, Walther M, Vestweber PK, Wachter J, Knoll P, Joergensen AM, Bernkop-Schnuerch A, Windbergs M. Journal of Controlled Release 2022, 348, 692-705. http://dx.doi.org/10.1016/j.jconrel.2022.06.023
• Molecular neuroscience community shares perspectives. Gura T, Acker-Palmer A, Kolodkin A, Meijers R, Mizuno N, Seiradake E, Tessier-Lavigne M. Neuron 2022, 110, 3656-3660. http://dx.doi.org/https://doi.org/10.1016/j.neuron.2022.10.029
• Application of confocal Raman microscopy for the characterization of topical semisolid formulations and their penetration into human skin ex vivo. Jung N, Namjoshi S, Mohammed Y, Grice JE, Benson HAE, Raney SG, Roberts MS, Windbergs M. Pharmaceutical Research 2022, 39, 935-948. http://dx.doi.org/10.1007/s11095-022-03245-7
• Assessing antigen presentation on the surface of Plasmodium falciparum-infected erythrocytes by photoactivated localization microscopy (PALM). Karathanasis C, Sanchez CP, Heilemann M, Lanzer M. In: ATR Jensen, L Hviid (eds). Malaria Immunology: Targeting the Surface of Infected Erythrocytes. 2022. Springer US, New York, NY, pp 457-466. http://dx.doi.org/10.1007/978-1-0716-2189-9_34
• Biochemical characterization of cell-free synthesized human β1 adrenergic receptor cotranslationally inserted into nanodiscs. Köck Z, Ermel U, Martin J, Morgner N, Achilleas Frangakis S, Dötsch V, Hilger D, Bernhard F. Journal of Molecular Biology 2022, 167687. http://dx.doi.org/https://doi.org/10.1016/j.jmb.2022.167687
• In vivo extracellular recordings of thalamic and cortical visual responses reveal V1 connectivity rules. Kraynyukova N, Renner S, Born G, Bauer Y, Spacek MA, Tushev G, Busse L, Tchumatchenko T. Proceedings of the National Academy of Sciences USA 2022, 119, e2207032119. http://dx.doi.org/doi:10.1073/pnas.2207032119
• Fast DNA-PAINT imaging using a deep neural network. Narayanasamy KK, Rahm JV, Tourani S, Heilemann M. Nature Communications 2022, 13, 5047. http://dx.doi.org/10.1038/s41467-022-32626-0
• Electrospun scaffolds as cell culture substrates for the cultivation of an in vitro blood-brain barrier model using human induced pluripotent stem cells. Rohde F, Danz K, Jung NA, Wagner S, Windbergs M. Pharmaceutics 2022, 14, 22. http://dx.doi.org/10.3390/pharmaceutics14061308
• In-situ tear fluid dissolving nanofibers enable prolonged viscosity-enhanced dual drug delivery to the eye. Rohde F, Walther M, Wachter J, Knetzger N, Lotz C, Windbergs M. International Journal of Pharmaceutics 2022, 616, 12. http://dx.doi.org/10.1016/j.ijpharm.2022.121513
• DeepBacs for multi-task bacterial image analysis using open-source deep learning approaches. Spahn C, Gómez-de-Mariscal E, Laine RF, Pereira PM, von Chamier L, Conduit M, Pinho MG, Jacquemet G, Holden S, Heilemann M, Henriques R. Communications Biology 2022, 5, 688. http://dx.doi.org/10.1038/s42003-022-03634-z
• In toto light sheet fluorescence microscopy live imaging datasets of Ceratitis capitata embryonic development. Strobl F, Schetelig MF, Stelzer EHK. Scientific Data 2022, 9, 340. http://dx.doi.org/10.1038/s41597-022-01443-x
• Synaptic plasticity controls the emergence of population-wide invariant representations in balanced network models. Timon LB, Ekelmans P, Konrad S, Nold A, Tchumatchenko T. Physical Review Research 2022, 4, 14. http://dx.doi.org/10.1103/PhysRevResearch.4.013162
• Unbiased choice of global clustering parameters for single-molecule localization microscopy. Verzelli P, Nold A, Sun C, Heilemann M, Schuman EM, Tchumatchenko T. Scientific Reports 2022, 12, 22561. http://dx.doi.org/10.1038/s41598-022-27074-1
• Physico-chemical analysis of electrospun fibers-A systematic approach. Walther M, Rohde F, Kielholz T, Windbergs M. European Journal of Pharmaceutics and Biopharmaceutics 2022, 171, 60-71. http://dx.doi.org/10.1016/j.ejpb.2022.01.001
• Dopamine and serotonin interplay for valence-based spatial learning. Wert-Carvajal C, Reneaux M, Tchumatchenko T, Clopath C. Cell Reports 2022, 39, 16. http://dx.doi.org/10.1016/j.celrep.2022.110645
• Cyclophilin anaCyp40 regulates photosystem assembly and phycobilisome association in a cyanobacterium. Yadav S, Centola M, Glaesmann M, Pogoryelov D, Ladig R, Heilemann M, Rai LC, Yildiz Ö, Schleiff E. Nature Communications 2022, 13, 1690. http://dx.doi.org/10.1038/s41467-022-29211-w

• Towards a Better Understanding of verapamil Release from Kollicoat SR:IR Coated Pellets Using Non-Invasive Analytical Tools. Fahier J, Vukosavljevic B, De Kinder L, Florin H, Goossens JF, Windbergs M, Siepmann F, Siepmann J, Muschert S. Pharmaceutics 2021, 13, 19. http://dx.doi.org/10.3390/pharmaceutics13101723
• Long-term live imaging and multiscale analysis identify heterogeneity and core principles of epithelial organoid morphogenesis. Hof L, Moreth T, Koch M, Liebisch T, Kurtz M, Tarnick J, Lissek SM, Verstegen MMA, van der Laan LJW, Huch M, Matthäus F, Stelzer EHK, Pampaloni F. BMC Biology 2021, 19, 37. http://dx.doi.org/10.1186/s12915-021-00958-w
• Non-invasive analysis of pancreas organoids in synthetic hydrogels defines material-cell interactions and luminal composition. Jung N, Moreth T, Stelzer EHK, Pampaloni F, Windbergs M. Biomaterials Science 2021, 9, 5485-5496. http://dx.doi.org/10.1039/d1bm00597a
• Therapy of infected wounds: overcoming clinical challenges by advanced drug delivery systems. Kaiser P, Wachter J, Windbergs M. Drug Delivery and Translational Research 2021, 11, 1545-1567. http://dx.doi.org/10.1007/s13346-021-00932-7
• An initiator- and catalyst-free hydrogel coating process for 3D printed medical-grade poly(epsilon-caprolactone). Loblein J, Lorson T, Komma M, Kielholz T, Windbergs M, Dalton PD, Luxenhofer R. Beilstein Journal of Organic Chemistry 2021, 17, 2095-2101. http://dx.doi.org/10.3762/bjoc.17.136
• The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner. Luck R, Karakatsani A, Shah B, Schermann G, Adler H, Kupke J, Tisch N, Jeong H-W, Back MK, Hetsch F, D’Errico A, De Palma M, Wiedtke E, Grimm D, Acker-Palmer A, von Engelhardt J, Adams RH, Augustin HG, Ruiz de Almodóvar C. Cell Reports 2021, 36, 109522. http://dx.doi.org/https://doi.org/10.1016/j.celrep.2021.109522
• Universal quenching of common fluorescent probes by water and alcohols. Maillard J, Klehs K, Rumble C, Vauthey E, Heilemann M, Fürstenberg A. Chemical Science 2021, 12, 1352-1362. http://dx.doi.org/10.1039/D0SC05431C
• Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53. Malkomes P, Lunger I, Oppermann E, Abou-El-Ardat K, Oellerich T, Günther S, Canbulat C, Bothur S, Schnütgen F, Yu W, Wingert S, Haetscher N, Catapano C, Dietz MS, Heilemann M, Kvasnicka H-M, Holzer K, Serve H, Bechstein WO, Rieger MA. Oncogene 2021, http://dx.doi.org/10.1038/s41388-021-01847-w
• Ex vivo visualization of RNA polymerase III-specific gene activity with electron microscopy. Manger S, Ermel UH, Frangakis AS. Communications Biology 2021, 4, 234. http://dx.doi.org/10.1038/s42003-021-01752-8
• Tightly coupled inhibitory and excitatory functional networks in the developing primary visual cortex. Mulholland HN, Hein B, Kaschube M, Smith GB. eLife 2021, 10, http://dx.doi.org/10.7554/eLife.72456; 10.7554/eLife.72456.sa1; 10.7554/eLife.72456.sa2
• Visualizing synaptic multi-protein patterns of neuronal tissue with DNA-assisted single-molecule localization microscopy. Narayanasamy KK, Stojic A, Li Y, Sass S, Hesse MR, Deussner-Helfmann NS, Dietz MS, Kuner T, Klevanski M, Heilemann M. Frontiers in Synaptic Neuroscience 2021, 13, 671288-671288. http://dx.doi.org/10.3389/fnsyn.2021.671288
• Neurovascular crosstalk coordinates the central nervous system development. Peguera B, Segarra M, Acker-Palmer A. Current Opinion in Neurobiology 2021, 69, 202-213. http://dx.doi.org/https://doi.org/10.1016/j.conb.2021.04.005
• QuickPIV: Efficient 3D particle image velocimetry software applied to quantifying cellular migration during embryogenesis. Pereyra M, Drusko A, Krämer F, Strobl F, Stelzer EHK, Matthäus F. BMC Bioinformatics 2021, 22, 579. http://dx.doi.org/10.1186/s12859-021-04474-0
• Blood-brain barrier dynamics to maintain brain homeostasis. Segarra M, Aburto MR, Acker-Palmer A. Trends in Neurosciences 2021, http://dx.doi.org/10.1016/j.tins.2020.12.002
• Light sheet fluorescence microscopy. Stelzer EHK, Strobl F, Chang B-J, Preusser F, Preibisch S, McDole K, Fiolka R,. Nature Reviews Methods Primers 2021, 1, 73. http://dx.doi.org/https://doi.org/10.1038/s43586-021-00069-4
• A deterministic genotyping workflow reduces waste of transgenic individuals by two-thirds. Strobl F, Stelzer EHK. Scientific Reports 2021, 11, 15325. http://dx.doi.org/10.1038/s41598-021-94288-0
• The prevalence and specificity of local protein synthesis during neuronal synaptic plasticity. Sun C, Nold A, Fusco CM, Rangaraju V, Tchumatchenko T, Heilemann M, Schuman EM. Science Advances 2021, 7, 13. http://dx.doi.org/10.1126/sciadv.abj0790
• Microbial cationic peptides as a natural defense mechanism against insect antimicrobial peptides. Vo TD, Spahn C, Heilemann M, Bode HB. ACS Chemical Biology 2021, http://dx.doi.org/10.1021/acschembio.0c00794
• Democratising deep learning for microscopy with ZeroCostDL4Mic. von Chamier L, Laine RF, Jukkala J, Spahn C, Krentzel D, Nehme E, Lerche M, Hernández-Pérez S, Mattila PK, Karinou E, Holden S, Solak AC, Krull A, Buchholz T-O, Jones ML, Royer LA, Leterrier C, Shechtman Y, Jug F, Heilemann M, Jacquemet G, Henriques R. Nature Communications 2021, 12, 2276. http://dx.doi.org/10.1038/s41467-021-22518-0
• Quantitative single-molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNF alpha-induced NF-& x138;B signaling. Weinelt N, Karathanasis C, Smith S, Medler J, Malkusch S, Fulda S, Wajant H, Heilemann M, van Wijk SJL. Journal of Leukocyte Biology 2021, 109, 363-371. http://dx.doi.org/10.1002/jlb.2ab0420-572rr

• Structure and mechanism of the Nap adhesion complex from the human pathogen Mycoplasma genitalium. Aparicio D, Scheffer MP, Marcos-Silva M, Vizarraga D, Sprankel L, Ratera M, Weber MS, Seybert A, Torres-Puig S, Gonzalez-Gonzalez L, Reitz J, Querol E, Piñol J, Pich OQ, Fita I, Frangakis AS. Nature Communications 2020, 11, 2877. http://dx.doi.org/10.1038/s41467-020-16511-2
• Carotid body Type I cells engage flavoprotein and Pin1 for oxygen sensing. Bernardini A, Wolf A, Brockmeier U, Riffkin H, Metzen E, Acker-Palmer A, Fandrey J, Acker H. American Journal of Physiology – Cell Physiology 2020, http://dx.doi.org/10.1152/ajpcell.00320.2019
• SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes. Bojkova D, Wagner JUG, Shumliakivska M, Aslan GS, Saleem U, Hansen A, Luxán G, Günther S, Pham MD, Krishnan J, Harter PN, Ermel UH, Frangakis AS, Milting H, Zeiher AM, Klingel K, Cinatl J, Dendorfer A, Eschenhagen T, Tschöpe C, Ciesek S, Dimmeler S. Cardiovascular Research 2020, http://dx.doi.org/10.1093/cvr/cvaa267
• Red light-triggered photoreduction on a nucleic acid template. Dutta S, Ruehle J, Schikora M, Deussner-Helfmann N, Heilemann M, Zatsepin T, Duchstein P, Zahn D, Knoer G, Mokhir A. Chemical Communications 2020, 56, 10026-10029. http://dx.doi.org/10.1039/d0cc03086d
• The transition from local to global patterns governs the differentiation of mouse blastocysts. Fischer SC, Corujo-Simon E, Lilao-Garzon J, Stelzer EHK, Muñoz-Descalzo S. PLoS One 2020, 15, e0233030. http://dx.doi.org/10.1371/journal.pone.0233030
• p63 uses a switch-like mechanism to set the threshold for induction of apoptosis. Gebel J, Tuppi M, Chaikuad A, Hötte K, Schröder M, Schulz L, Löhr F, Gutfreund N, Finke F, Henrich E, Mezhyrova J, Lehnert R, Pampaloni F, Hummer G, Stelzer EHK, Knapp S, Dötsch V. Nature Chemical Biology 2020, 16, 1078-1086. http://dx.doi.org/10.1038/s41589-020-0600-3
• Multi-color, bleaching-resistant super-resolution optical fluctuation imaging with oligonucleotide-based exchangeable fluorophores. Glogger M, Spahn C, Enderlein J, Heilemann M. Angewandte Chemie 2020, http://dx.doi.org/10.1002/anie.202013166
• p120-catenin-dependent collective brain infiltration by glioma cell networks. Gritsenko PG, Atlasy N, Dieteren CEJ, Navis AC, Venhuizen JH, Veelken C, Schubert D, Acker-Palmer A, Westerman BA, Wurdinger T, Leenders W, Wesseling P, Stunnenberg HG, Friedl P. Nature Cell Biology 2020, 22, 97-107. http://dx.doi.org/10.1038/s41556-019-0443-x
• Selective modulator of peroxisome proliferator-activated receptor gamma with an unprecedented binding mode. Hanke T, Cheung SY, Kilu W, Heering J, Ni XM, Planz V, Schierle S, Faudone G, Friedrich M, Wanior M, Werz O, Windbergs M, Proschak E, Schubert-Zsilavecz M, Chaikuad A, Knapp S, Merk D. Journal of Medicinal Chemistry 2020, 63, 4555-4561. http://dx.doi.org/10.1021/acs.jmedchem.9b01786
• Single-molecule super-resolution microscopy reveals heteromeric complexes of MET and EGFR upon ligand activation. Harwardt M-LIE, Schroeder MS, Li Y, Malkusch S, Freund P, Gupta S, Janjic N, Strauss S, Jungmann R, Dietz MS, Heilemann M. International Journal of Molecular Sciences 2020, 21, http://dx.doi.org/10.3390/ijms21082803
• First structure-activity relationship study of potent BLT2 agonists as potential wound-healing promoters. Hernandez-Olmos V, Heering J, Planz V, Liu T, Kaps A, Rajkumar R, Gramzow M, Kaiser A, Schubert-Zsilavecz M, Parnham MJ, Windbergs M, Steinhilber D, Proschak E. Journal of Medicinal Chemistry 2020, 63, 11548-11572. http://dx.doi.org/10.1021/acs.jmedchem.0c00588
• Quantitative single-molecule localization microscopy reports on protein numbers in signaling protein complexes. Karathanasis C, Baldering TN, Boeger C, Harwardt M-LIE, Li Y, Schroeder MS, Deussner-Helfmann NS, Glaesmann M, Malkusch S, Dietz MS, Hafner A-S, Schuman E, Hummer G, Heilemann M. In: I Gregor, F Koberling, R Erdmann (eds). Single Molecule Spectroscopy and Superresolution Imaging XIII. 2020. (Proceedings of SPIE vol 11246). http://dx.doi.org/10.1117/12.2550635
• Single-molecule imaging reveals the oligomeric state of functional TNFalpha-induced plasma membrane TNFR1 clusters in cells. Karathanasis C, Medler J, Fricke F, Smith S, Malkusch S, Widera D, Fulda S, Wajant H, van Wijk SJL, Dikic I, Heilemann M. Science Signaling 2020, 13, published online 16 January 2020. http://dx.doi.org/10.1126/scisignal.aax5647
• Automated highly multiplexed super-resolution imaging of protein nano-architecture in cells and tissues. Klevanski M, Herrmannsdoerfer F, Sass S, Venkataramani V, Heilemann M, Kuner T. Nature Communications 2020, 11, http://dx.doi.org/10.1038/s41467-020-15362-1
• A mechanochemical model for rho GTPase mediated cell polarization. Kopfer KH, Jager W, Matthäus F. Journal of Theoretical Biology 2020, 504, 13. http://dx.doi.org/10.1016/j.jtbi.2020.110386
• Specific, targetable interactions with the microenvironment influence imatinib-resistant chronic myeloid leukemia. Kumar R, Pereira RS, Zanetti C, Minciacchi VR, Merten M, Meister M, Niemann J, Dietz MS, Ruessel N, Schnuetgen F, Tamai M, Akahane K, Inukai T, Oellerich T, Kvasnicka HM, Pfeifer H, Nicolini FE, Heilemann M, Van Etten RA, Krause DS. Leukemia 2020, 34, 2087-2101. http://dx.doi.org/10.1038/s41375-020-0866-1
• Cell fate clusters in ICM organoids arise from cell fate heredity and division: a modelling approach. Liebisch T, Drusko A, Mathew B, Stelzer EHK, Fischer SC, Matthäus F. Scientific Reports 2020, 10, 11. http://dx.doi.org/10.1038/s41598-020-80141-3
• Nonlinear response characteristics of neural networks and single neurons undergoing optogenetic excitation. Luboeinski J, Tchumatchenko T. Network Neuroscience 2020, 4, 852-870. http://dx.doi.org/10.1162/netn_a_00154
• Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors. Möller J, Isbilir A, Sungkaworn T, Osberg B, Karathanasis C, Sunkara V, Grushevskyi EO, Bock A, Annibale P, Heilemann M, Schütte C, Lohse MJ. Nature Chemical Biology 2020, http://dx.doi.org/10.1038/s41589-020-0566-1
• How repair-or-dispose decisions under stress can initiate disease progression. Nold A, Batulin D, Birkner K, Bittner S, Tchumatchenko T. iScience 2020, 23, 31. http://dx.doi.org/10.1016/j.isci.2020.101701
• Current progress in particle-based systems for transdermal vaccine delivery. Pielenhofer J, Sohl J, Windbergs M, Langguth P, Radsak MP. Frontiers in Immunology 2020, 11, 8. http://dx.doi.org/10.3389/fimmu.2020.00266
• Measuring stepwise binding of thermally fluctuating particles to cell membranes without fluorescence. Rohrbach A, Meyer T, Stelzer EHK, Kress H. Biophysical Journal 2020, 118, 1850-1860. http://dx.doi.org/10.1016/j.bpj.2020.03.005
• Statistical laws of protein motion in neuronal dendritic trees. Sartori F, Hafner AS, Karimi A, Nold A, Fonkeu Y, Schuman EM, Tchumatchenko T. Cell Reports 2020, 33, 18. http://dx.doi.org/10.1016/j.celrep.2020.108391
• Imaging the fibroblast growth factor receptor network on the plasma membrane with DNA-assisted single-molecule super-resolution microscopy. Schroder MS, ML IEH, Rahm JV, Li Y, Freund P, Dietz MS, Heilemann M. Methods 2020, http://dx.doi.org/10.1016/j.ymeth.2020.05.004
• Cysteine oxidation and disulfide formation in the ribosomal exit tunnel. Schulte L, Mao J, Reitz J, Sreeramulu S, Kudlinzki D, Hodirnau VV, Meier-Credo J, Saxena K, Buhr F, Langer JD, Blackledge M, Frangakis AS, Glaubitz C, Schwalbe H. Nature Communications 2020, 11, 5569. http://dx.doi.org/10.1038/s41467-020-19372-x
• Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography. Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS. Proceedings of the National Academy of Sciences USA 2020, 117, 27132-27140. http://dx.doi.org/10.1073/pnas.2004563117
• A survey of within-host and between-hosts modelling for antibiotic resistance. Tetteh JNA, Matthäus F, Hernandez-Vargas EA. Biosystems 2020, 196, 13. http://dx.doi.org/10.1016/j.biosystems.2020.104182
• Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae. Vizarraga D, Kawamoto A, Matsumoto U, Illanes R, Perez-Luque R, Martin J, Mazzolini R, Bierge P, Pich OQ, Espasa M, Sanfeliu I, Esperalba J, Fernandez-Huerta M, Scheffer MP, Pinyol J, Frangakis AS, Lluch-Senar M, Mori S, Shibayama K, Kenri T, Kato T, Namba K, Fita I, Miyata M, Aparicio D. Nature Communications 2020, 11, 16. http://dx.doi.org/10.1038/s41467-020-18777-y
• Inhibition of tumor VEGFR2 induces serine 897 EphA2-dependent tumor cell invasion and metastasis in NSCLC. Volz C, Breid S, Selenz C, Zaplatina A, Golfmann K, Meder L, Dietlein F, Borchmann S, Chatterjee S, Siobal M, Schottle J, Florin A, Koker M, Nill M, Ozretic L, Uhlenbrock N, Smith S, Buttner R, Miao H, Wang B, Reinhardt HC, Rauh D, Hallek M, Acker-Palmer A, Heukamp LC, Ullrich RT. Cell Reports 2020, 31, 107568. http://dx.doi.org/10.1016/j.celrep.2020.107568
• Early developmental plasticity of lateral roots in response to asymmetric water availability. von Wangenheim D, Banda J, Schmitz A, Boland J, Bishopp A, Maizel A, Stelzer EHK, Bennett M. Nature Plants 2020, 6, 73-77. http://dx.doi.org/10.1038/s41477-019-0580-z
• Controlling supramolecular structures of drugs by light. Wiest J, Kehrein J, Saedtler M, Schilling K, Cataldi E, Sotriffer CA, Holzgrabe U, Rasmussen T, Bottcher B, Cronin-Golomb M, Lehmann M, Jung N, Windbergs M, Meinel L. Molecular Pharmaceutics 2020, 17, 4704-4708. http://dx.doi.org/10.1021/acs.molpharmaceut.0c00720

Selected publications of the members of iMOL prior to 2020

• Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system. Segarra M, Aburto MR, Cop F, Llaó-Cid C, Härtl R, Damm M, Bethani I, Parrilla M, Husainie D, Schänzer A, Schlierbach H, Acker T, Mohr L, Torres-Masjoan L, Ritter M, Acker-Palmer A. Science 2018, 361:6404.
• GRIP1 regulates ApoER2/ephrinB2 functions at the synapse. Pfennig S#, Foss F#, Bissen D, Harde E, TreeckJ, Segarra M and Acker-Palmer A. Cell Reports 2017, 21:84-96.
• EphrinB2 repression mediates tumor invasion and evasive resistance to anti-angiogenesis. Depner C, ZumButtel H, Böğürcü N, Cuesta AM, Aburto MR, Seidel S, Finkelmeier F, Foss F, Hofmann J, Kaulich K, Barbus S, Segarra M, Reifenberger G, Garvalov BK, Acker T,* Acker-Palmer A*. Nature Communications 2016, 7:12329 *equal contribution.
• Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR. Henze AT, Garvalov BK, Seidel S, Cuesta A, Ritter M, Filatova A, Foss F, Dopeso H, Essmann CL, Maxwell PH, Reifenberger G, Carmeliet P, Acker-Palmer A*, Acker T*. Nature Communications 2014, 5:5582 *equal contribution.
• PHD3 regulates EGFR internalization and signaling in tumours. Garvalov BK*, Foss F*, Henze, AT, Bethani I, Gräf-Höchst S, Singh D, Filatova A, Dopeso H, Seidel S, Damm M, Acker-Palmer A*, Acker T*. Nature Communications 2014, 5:5577 *equal contribution.
• The GRIP1/14-3-3 pathway coordinates cargo trafficking and dendrite development. Geiger JC, Lipka J, Segura I, Hoyer S, Schlager MA, Wulf PS, Weinges S, Demmers J, Hoogenraad CC, Acker-Palmer A. Developmental Cell 2014, 28:381-393.
• EphrinBs are essential components of the Reelin pathway to regulate neuronal migration. Senturk A., Pfennig S, Weiss A, Burk K, Acker-Palmer, A. Nature 2011, 472:356-60 (Erratum 478:274).
• EphrinB2 regulates VEGFR2 function in developmental and tumour angiogenesis. Sawamiphak S, Seidel S, Essmann CL, Wilkinson G, Pitulescu ME, Acker T, Acker-Palmer A. Nature 2010, 465:487-491.
• Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors. Essmann CL, Martinez E, Geiger J, Zimmer M, Traut M, Stein V, Klein R, Acker-Palmer A. Nature Neuroscience 2008, 11:1035-1043.
• Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Segura I, Essmann CL, Weinges S, Acker-Palmer A. Nature Neuroscience 2007, 10:301-310.
• Cryo-electron tomography analyses of terminal organelle mutants suggest the motility mechanism of Mycoplasma genitalium. Seybert A, Gonzalez-Gonzalez L, Scheffer MP, Lluch-Senar M, Mariscal AM,Querol E, Matthaeus F, Piñol J, Frangakis AS. Molecular Microbiology 2018, 319-329. doi: 10.1111/mmi.13938.
• Structural characterization of the NAP; the major adhesion complex of the human pathogen Mycoplasma genitalium. Scheffer MP, Gonzalez-Gonzalez L, Seybert A, Ratera M, Kunz M, Valpuesta JM, Fita I, Querol E, Piñol J, Martín-Benito J, Frangakis AS. Molecular Microbiology 2017, 105, 869-879.
• Structure of RNA polymerase I transcribing ribosomal DNA genes. Neyer S, Kunz M, Geiss C, Hantsche M; Hodirnau VV, Seybert A, Engel C, Scheffer MP, Cramer P, Frangakis AS. Nature 2016, 540, 607-610.
• Three-dimensional CTF correction improves the resolution of electron tomograms. Kunz M, Frangakis AS. J Structural Biology 2016, 197, 114-122.
• Quantitative analysis of cytoskeletal reorganization during epithelial tissue sealing by large-volume electron tomography. Eltsov M, Dubé N, Yu Z, Pasakarnis L, Haselmann-Weiss U, Brunner D, Frangakis AS. Nature Cell Biology 2015, 17, 605-614.
• Super-sampling SART with ordered subsets. Kunz M, Frangakis AS. J Structural Biology 2014, 188, 107-115.
• M-free: scoring the reference bias in sub-tomogram averaging and template matching. Yu Z, Frangakis AS. J Structural Biology 2014, 187, 10-19.
• Correlative Light- and Electron Microscopy with chemical tags. Perkovic M, Kunz M, Endesfelder U, Bunse S, Wigge C, Yu Z, Hodirnau VV, SchefferMP, Seybert A, Malkusch S, Schuman EM, Heilemann M, FrangakisAS. J Structural Biology 2014, 186, 205-213.
• Heritable yeast prions have a highly organized three-dimensional architecture with interfiber structures. SaibilHR, Seybert A, Habermann A, Winkler J, Eltsov M, Perkovic M, Castaño-Diez D, Scheffer MP, HaselmannU, Chlanda P, Lindquist S, Tyedmers J, Frangakis AS. Proceedings of the National Academy of Sciences USA 2012, 109, 14906-14911.
• Evidence for short-range helical order in the 30-nm chromatin fibers of erythrocyte nuclei. Scheffer MP, EltsovM, Frangakis AS. Proceedings of the National Academy of Sciences USA 2011, 108, 16992-16997.
• The molecular architecture of cadherins in native epidermal desmosomes. Al-Amoudi A, Díez DC, Betts MJ, Frangakis AS. Nature 2007, 450, 832-837.
• Whole-cell, 3D and multicolor STED imaging with exchangeable fluorophores. Spahn C, Grimm JB, Lavis LD, Lampe M, Heilemann M*. Nano Letters 2019, 19, 500-505.
• Correlative Single-Molecule FRET and DNA-PAINT Imaging Deussner-Helfmann NS, Auer A, Strauss MT, Malkusch S, Dietz MS, Barth HD, Jungmann R, Heilemann M*. Nano Letters 2018, 16, 4626-30.
• Quantitative single-molecule imaging of TLR4 reveals ligand-specific receptor dimerization. Krüger CL, ZeunerMT, Cottrell GS, Widera D, Heilemann M*. Science Signaling 2017,10, eaan1308.
• Linear ubiquitination of cytosolic Salmonella locally activates NF-ĸB and restricts bacterial proliferation. Van Wijk SJL, Fricke F, Herhaus L, Hötte K, Pampaloni F, Fulda S, Heilemann M*, Dikic I*. Nature Microbiology 2017, 8, 2:17066.
• Temporal accumulation analysis provides simplified artifact-free analysis of membrane-protein nanoclusters. Spahn C, Herrmannsdörfer F, Kuner T, Heilemann M*. Nature Methods 2016, 13, 963-964.
• A set of homo-oligomeric standards allows accurate protein counting. Finan K, Raulf A, Heilemann M*. Angewandte Chemie 2015, 54, 12049-52.
• SLAP: Small labelling pair for single-molecule super-resolution imaging. Wieneke R, Raulf A, KollmanspergerA, Heilemann M*, Tampé R*. Angewandte Chemie 2015, 54, 10216-9.
• Arts and artifacts in single-molecule localization microscopy – beyond attractive images. Endesfelder U, Heilemann M*. Nature Methods 2014, 11(3), 235-8.
• Super-resolution fluorescence imaging of chromosomal DNA using click chemistry. Zessin P, Finan K, Heilemann M*. Journal of Structural Biology 2012, 177, 344-348.
• Monitoring multiple distances within a single molecule using switchable FRET. Uphoff S, Holden SJ, Le Rest L, Periz J, van de Linde S, Heilemann M, Kapanidis AN. Nature Methods 2010, 7, 831-6.
• Distributed network interactions and their emergence in developing neocortex. Smith GB, Hein B, Whitney DE, Fitzpatrick D*, Kaschube M*. Nature Neuroscience 2018, 21:1600-1608. *jointly directed work
• Elucidating the control and development of skin patterning in cuttlefish. Reiter S, Hülsdunk P, Woo T, Lauterbach MA, Eberle JS, Akay LA, Longo A, Meier-Credo J, Kretschmer F, Langer JD, Kaschube M, Laurent G. Nature 2018, 562:361-366.
• The development of cortical circuits for motion discrimination. Smith GB, Sederberg A, Elyada YM, Van HooserSD, Kaschube M*, Fitzpatrick D*. Nature Neuroscience 2015, 18:252-261. *jointly directed work
• Quantitative 4D analyses of epithelial folding during Drosophila gastrulation. Khan Z, Wang YC, Wieschaus EF, Kaschube M. Development 2014, 141:2895-2900.
• Volume conservation principle involved in cell lengthening and nucleus movement during tissue morphogenesis. Gelbart MA, He B, Martin AC, Thiberge SY, Wieschaus EF, Kaschube M. Proceedings of the National Academy of Sciences USA 2012,109:19298-19303.
• Differential positioning of adherens junctions is associated with initiation of epithelial folding. Wang YC, Khan Z, Kaschube M, Wieschaus EF. Nature 2012, 484:390-393.
• Universality in the evolution of orientation columns in the visual cortex. Kaschube M, Schnabel M, Löwel S, Coppola DM, White LE, Wolf F. Science 2010, 330:1113-1116.
• Reorganization of columnar architecture in the growing visual cortex. Keil W, Schmidt K-F, Löwel S, Kaschube M. Proceedings of the National Academy of Sciences USA 2010, 107:12293-12298.
• Pulsed contractions of an actin-myosin network drive apical constriction. Martin AC, Kaschube M, WieschausEF. Nature 2009, 457:495-499.
• Interareal coordination of columnar architectures during visual cortical development. Kaschube M, Schnabel M, Wolf F, Löwel S. Proceedings of the National Academy of Sciences USA 2009, 106:17205-17210.
• Interacting signalling and cellular waves pattern the feather array. W.K.W. Ho, L. Freem, D. Zhao, M.J. McGrew, K.J. Painter, T. Woolley, E. A. Gaffney, A. Tzika, M. Milinkovitch, P. Schneider, A. Drusko, F. Matthäus, J.L. Glover, H.M. Sang, M.G. Davey, K.L. Wells, J.A. Johansson, M. Clinton, D.J. Headon. PLoS Biology 2019, 17 (2), e3000132.
• Hierarchical patterning modes orchestrate hair follicle morphogenesis. J.D. Glover, K.L. Wells, F. Matthäus, K.J. Painter, W. Ho, J. Riddell, J.A. Johansson, M. Ford, C.A.B. Jahoda, V. Klika, R.L. Mort, and D.J. Headon. PLoS Biology 2017, 15(7):e2002117.
• An individual-based model for the collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors. D. Stichel, A.M. Middleton, B.F. Müller, S. Depner, U. Klingmüller, K. Breuhahn, F. Matthäus. NPJ Systems Biology and Applications 2017, 3, Art. no. 5, DOI:10.1038/s41540-017-0006-3.
• TCCA: An R package for the identification of differentially expressed genes in time course microarray data. M. Albrecht, D. Stichel, B.F. Müller, R. Merkle, C. Sticht, N. Gretz, U. Klingmüller, K. Breuhahn, F. Matthäus.BMC Bioinformatics 2017, 18:33.
• Concomitant expression of far upstream element (FUSE) binding protein (FBP) interacting repressor (FIR) and its splice variants induce migration and invasion of non-small cell lung cancer (NSCLC) cells. B. Müller*, M. Bovet*, Y. Yin*, D. Stichel*, M. Malz, A.M. Middleton, V. Ehemann, J. Schmitt, T. Muley, M. Meister, E. Herpel, S. Singer, A. Warth, P. Schirmacher, D. Drasdo$, F. Matthäus$, K. Breuhahn$. Journal of Pathology 2015, 237:390-401. http://dx.doi.org/https://doi.org/10.1002/path.4588
• Stathmin regulates keratinocyte proliferation and migration during cutaneous regeneration. S. Schmitt, K. Safferling, K. Westphal, M. Hrabowski, U. Müller, P. Angel, L. Wiechert, V. Ehemann, B. Müller, S. Holland-Cunz, D. Stichel, N. Harder, K. Rohr, G. Germann, F. Matthäus, P. Schirmacher, N. Grabe, K. Breuhahn. PLoS One 2013, 8(9): e75075.
• Effects of age on the structure of functional connectivity networks during episodic and working memory demand. F. Matthäus, J.-P. Schmidt, A. Banerjee, T.G. Schulze, T. Demirakca, C. Diener. Brain Connectivity 2012, 2(3), DOI: 10.1089/brain.2012.0077.
• On the origin and characteristics of noise-induced Lévy walks of E. coli. F. Matthäus, M.S. Mommer, T. Curk, J. Dobnikar. PLoS One 2011, 6(4):e18623.
• E. coli superdiffusion and chemotaxis – search strategy, precision and motility. F. Matthäus, M. Jagodič, J. Dobnikar. Biophysical Journal 2009, 97(4): 946-957.
• A universal vector concept for a direct genotyping of transgenic organisms and a systematic creation of homozygous lines. Strobl F, Anderl A, Stelzer EHK. eLife 2018, 7:e31677. doi: 10.7554/eLife.31677.
• Oocyte DNA damage quality control requires consecutive interplay of CHK2 and CK1 to activate p63. Tuppi M, Kehrloesser S, Coutandin DW, Rossi V, Luh LM, Strubel A, Hötte K, Hoffmeister M, Schäfer B, De Oliveira T, Greten F, Stelzer EHK, Knapp S, De Feliciv M, Behrends C, Klinger FG, Dötsch V. Nature Structural & Molecular Biology 2018, 25, 261–269. doi:10.1038/s41594-018-0035-7.
• csiLSFM combines light-sheet fluorescence microscopy and coherent structured illumination for a lateral resolution below 100 nm. Chang BJ, Perez Meza VD, Stelzer EHK. Proceedings of the National Academy of Sciences USA 2017, 114(19):4869-4874.
• Rules and Self-Organizing Properties of Post-embryonic Plant Organ Cell Division Patterns, von Wangenheim D, Fangerau J, Schmitz A, Smith RS, Leitte H, Stelzer EHK, Maizel A. Current Biology 2016, 26:1-11.
• Live imaging of Tribolium castaneum embryonic development using light-sheet–based fluorescence microscopy. Strobl F, Schmitz A,Stelzer EHK. Nature Protocols 2015, 10:1486.1507.
• Light-sheet fluorescence microscopy for quantitative biology. Stelzer EHK. Nature Methods 2015, 12(1):23-27.
• Fast, high-contrast imaging of animal development with scanned light sheet-based structured-illumination microscopy. Keller PJ, Schmidt AD, Santella A, Khairy K, Bao Z, Wittbrodt J, Stelzer EHK. Nature Methods 2010, 7(8):637-642.
• The third dimension bridges the gap between cell culture and live tissue. Pampaloni F, Reynaud EG, Stelzer EHK. Nature Reviews Molecular Cell Biology 2007, 8(10):839-845.
• Reconstruction of zebrafish early embryonic development by Scanned Light Sheet Microscopy. Keller PJ, Schmidt AD, Wittbrodt J, Stelzer EHK. Science 2008, 322(5904):1065-1069.
• Optical sectioning deep inside live embryos by selective plane illumination microscopy. Huisken J, Swoger J, Del Bene F, Wittbrodt J, Stelzer EHK. Science 2004, 305:1007-1009.
• How mRNA localization and protein synthesis sites influence dendritic protein distribution and dynamics. Fonkeu Y, Kraynuykova N, Hafner A-S, Sartori F, Schuman EM, Tchumatchenko T. Neuron 2019, doi: 10.1016/j.neuron.2019.06.022.
• Stabilized supralinear network can give rise to bistable, oscillatory and persistent activity. Kraynyukova N, Tchumatchenko T. Proceedings of the National Academy of Sciences USA 2018, 201700080.
• How linear response shaped models of neural circuits and the quest for alternative. Herfurth T, Tchumatchenko T. Current Opinion in Neurobiology 2017, 6, 234-240. http://dx.doi.org/https://doi.org/10.1016/j.conb.2017.09.001
• Pairwise spike correlations fully capture the information content of a neuron. Dettner A, Muenzberg S, Tchumatchenko T. Nature Communcations 2016, 7, 13805.
• Synaptic unreliability facilitates information transmission in balanced cortical populations. Gatys LA, Ecker AS, Tchumatchenko T, Bethge M. Physical Review E 2015, 91, 062707. http://dx.doi.org/10.1103/PhysRevE.91.062707
• Oscillations emerging from noise-driven steady state in networks with electrical synapses and subthreshold resonance. Tchumatchenko T, Clopath C. Nature Communications 2014, 5, 5512.
• A cochlear-bone wave can yield hearing sensation as well as otoacoustic emission. Tchumatchenko T, Reichenbach T. Nature Communications 2014, 5, 4160.
• Ultrafast population encoding by cortical neurons. T. Tchumatchenko, A. Malyshev, F. Wolf and M. Volgushev. Journal of Neuroscience 2011, 31 (34) 12171-12179. http://dx.doi.org/10.1523/jneurosci.2182-11.2011
• Delivery of time-varying stimuli using ChR2. Tchumatchenko T, Newman JP, Fong M-F, Potter S. Frontiers in Neural Circuits 2013, 7:184. http://dx.doi.org/10.3389/fncir.2013.00184
• Correlations and synchrony in threshold neuron models. T. Tchumatchenko, A. Malyshev, T. Geisel, M. Volgushev and F. Wolf. Physical Review Letters 2010, 104 (5), 058102.
• Vibrational spectroscopic imaging and live cell video microscopy for studying differentiation of primary human alveolar epithelial cells. Vukosavljevic B, Hittinger M, Hachmeister H, Pilger C, Murgia X, Gepp M, Gentile L, Huwer H, Schneider-Daum N, Huser T, Lehr CM, Windbergs M. Journal of Biophotonics 2019, e201800052.
• Tracing molecular and structural changes upon mucolysis with N-acetyl cysteine in human airway mucus. Vukosavljevic B, Murgia X, Schwarzkopf K, Schaefer UF, Lehr CM, Windbergs M. International Journal of Pharmceutics 2017, 533, 373-376.
• Intracellular delivery of poorly soluble polyphenols – elucidating the interplay of self-assembling nanocarriers and human chondrocytes. Kann B, Spengler C, Coradini K, Rigo LA, Bennink M, Jacobs K, Offerhaus HL, Beck RCR, Windbergs M. Analytical Chemistry 2016, 88, 7014-7022. http://dx.doi.org/10.1021/acs.analchem.6b00199
• Three-dimensional hierarchical cultivation of human skin cells on bio-adaptive hybrid fibers. Planz V, Seif S, Atchinson J, Vukosavljevic B, Sparenberg L, Kroner E, Windbergs M. Integrative Biology 2016, 8, 775-784.
• Skin penetration behaviour of lipid-core nanocapsules for simultaneous delivery of resveratrol and curcumin. Friedrich RB, Coradini K, Kann B, Beck RCR, Windbergs M. European Journal of Pharmaceutical Sciences 2015, 78, 204-213.
• Overcoming drug crystallization in electrospun fibers – elucidating key parameters and developing strategies for drug delivery. Seif S, Franzen L, Windbergs M. International Journal of Pharmaceutics 2015, 478, 390-397.
• Biodegradable core-shell carriers for simultaneous encapsulation of synergistic actives. Windbergs M, HeymanJ, Zhao J, Weitz DA. Journal of the American Chemical Society 2013, 135, 7933-7937. Featured in Science 2013, 340, 1016-1017.
• Towards drug quantification in human skin with confocal Raman microscopy. Franzen L, Selzer D, Fluhr J, Schaefer UF, Windbergs M. European Journal of Pharmaceutics and Biopharmaceutics 2013, 84, 437-444.
• Drug dissolution chip (DDC): a microfluidic approach for drug release. Windbergs M, Weitz DA. Small 2011, 7, 3011-3015.
• Budesonide loaded nanoparticles with pH-sensitive coating for improved mucosal targeting in inflammatory bowel diseases. Ali H, Weigmann B, Neurath MF, Collnot EM, Windbergs M, Lehr CM. Journal of Controlled Release 2014, 183, 167-177.