Project B2: Electron tomography of cell-cell junctions to address the Blood-Brain-Barrier using correlative light and electron microscopy methodologies
Work package 1: Visualization of cell-cell junctions using cryo-ET
Work package 2: Mechanism of BBB disruption in Reelin-deficient mice using cryo-ET
Figure: An example of a cryo-electron tomogram of a cell-cell junction.
Computational Biophysics: Ranking the Model Plethora
Can we discriminate different models using molecular dynamics simulations?
Figure: Molecular dynamics simulations
Figure: Molecular model of a cell-cell junction