iMOL Research Training Group 2566

 

 

 

• A1 (Ernst Stelzer): Light sheet-based fluorescence microscopy, sample holder systems, high-throughput/high-content LSFM
  • Work package 1: Meticulous description of the image recording process in mathematical, physical and engineering terms: Device-dependent metadata
  • Work package 2: Recording image data in event-driven adaptive feedback loops: Experiment-dependent metadata
  • Work package 3: Applications of event-driven adaptive feedback loops
• A2 (Mike Heilemann): Accelerate and simplify super-resolution imaging techniques
  • Work package 1: Machine learning-assisted SMLM
  • Work package 2: Novel imaging and machine-learning tools for multi-color SMLM
• A3 (Achilleas Frangakis): New image registration and reconstruction tools for electron tomography
  • Work package 1: Improved reconstruction strategies and local alignment procedures
  • Work package 2: Improved denoising methods
• B1 (Amparo Acker-Palmer): Imaging the neurovascular interface
  • Work package 1: Imaging the neurovascular interface in the developing hippocampus
  • Work package 2: Imaging the neurovascular interface in the zebrafish
• B2 (Amparo Acker-Palmer & Achilleas Frangakis): Electron tomography of cell-cell junctions to address the BBB using correlative light and electron microscopy methodologies
  • Work package 1: Visualization of cell-cell junctions using cryo-ET
  • Work package 2: Mechanism of BBB disruption in Reelin-deficient mice using cryo-ET
• B3 (Maike Windbergs & Ernst Stelzer): 3D insights into cellular processes governing wound healing and tissue regeneration
  • Work package 1: Imaging skin wounds and reepithelization
  • Work package 2: Analysis of individual keratinocytes during reepithelization
  • Work package 3: Investigating modulation and control of wound reepithelization
• B4 (Maike Windbergs): Investigation of neurodegenerative disorders using Raman microscopy
  • Work package 1: Investigating Aβ peptides during aggregation and plaque formation
  • Work package 2: In vitro / in vivo correlation of plaque formation
  • Work package 3: Dynamic interaction of Aβ aggregates and the BBB on a chip
• B5 (Mike Heilemann & Tatjana Tchumatchenko): Structure identification in single particle velocity vectors
  • Work package 1: Computational analysis of the receptor dynamics
  • Work package 2: NN-based modelling
• C1 (Tatjana Tchumatchenko): Identifying signatures of prospective and retrospective coding in multi-cell data
  • Work package 1: Use of an autoencoder to analyze the cortical network activity
  • Work package 2: Principle components analysis (PCA) for the analysis of the networks
• C2 (Matthias Kaschube): Segmentation, tracking, and pattern recognition for molecular biology
  • Work package 1: Turning images into numbers: segmentation, tracking and nonlinear mapping of biological tissues, cells, and cellular components
  • Work package 2: Tracking of cells and cellular components
• C3 (Franziska Matthaeus): Analysis of cell motility and cell-cell interactions for multicellular systems
  • Work package 1: Approaches for quantitative analyses of collective cell migration
  • Work package 2: Quantification of cell deformations
  • Work package 3: Estimation of forces based on deformations and cell motion
• C4 (Kaschube, Stelzer, Matthaeus, Frangakis): Optimization and acceleration of image processing algorithms
  • Work package 1: Development of the toolbox
  • Work package 2: Increasing the speed and reaching platform independence