iMOL Research Training Group 2566
- A1 (Ernst Stelzer): Light sheet-based fluorescence microscopy, sample holder systems, high-throughput/high-content LSFM
- Work package 1: Meticulous description of the image recording process in mathematical, physical and engineering terms: Device-dependent metadata
- Work package 2: Recording image data in event-driven adaptive feedback loops: Experiment-dependent metadata
- Work package 3: Applications of event-driven adaptive feedback loops
- A2 (Mike Heilemann): Accelerate and simplify super-resolution imaging techniques
- Work package 1: Machine learning-assisted SMLM
- Work package 2: Novel imaging and machine-learning tools for multi-color SMLM
- A3 (Achilleas Frangakis): New image registration and reconstruction tools for electron tomography
- Work package 1: Improved reconstruction strategies and local alignment procedures
- Work package 2: Improved denoising methods
- B1 (Amparo Acker-Palmer): Imaging the neurovascular interface
- Work package 1: Imaging the neurovascular interface in the developing hippocampus
- Work package 2: Imaging the neurovascular interface in the zebrafish
- B2 (Amparo Acker-Palmer & Achilleas Frangakis): Electron tomography of cell-cell junctions to address the BBB using correlative light and electron microscopy methodologies
- Work package 1: Visualization of cell-cell junctions using cryo-ET
- Work package 2: Mechanism of BBB disruption in Reelin-deficient mice using cryo-ET
- B3 (Maike Windbergs & Ernst Stelzer): 3D insights into cellular processes governing wound healing and tissue regeneration
- Work package 1: Imaging skin wounds and reepithelization
- Work package 2: Analysis of individual keratinocytes during reepithelization
- Work package 3: Investigating modulation and control of wound reepithelization
- B4 (Maike Windbergs): Investigation of neurodegenerative disorders using Raman microscopy
- Work package 1: Investigating Aβ peptides during aggregation and plaque formation
- Work package 2: In vitro / in vivo correlation of plaque formation
- Work package 3: Dynamic interaction of Aβ aggregates and the BBB on a chip
- B5 (Mike Heilemann & Tatjana Tchumatchenko): Structure identification in single particle velocity vectors
- Work package 1: Computational analysis of the receptor dynamics
- Work package 2: NN-based modelling
- C1 (Tatjana Tchumatchenko): Identifying signatures of prospective and retrospective coding in multi-cell data
- Work package 1: Use of an autoencoder to analyze the cortical network activity
- Work package 2: Principle components analysis (PCA) for the analysis of the networks
- C2 (Matthias Kaschube): Segmentation, tracking, and pattern recognition for molecular biology
- Work package 1: Turning images into numbers: segmentation, tracking and nonlinear mapping of biological tissues, cells, and cellular components
- Work package 2: Tracking of cells and cellular components
- C3 (Franziska Matthaeus): Analysis of cell motility and cell-cell interactions for multicellular systems
- Work package 1: Approaches for quantitative analyses of collective cell migration
- Work package 2: Quantification of cell deformations
- Work package 3: Estimation of forces based on deformations and cell motion
- C4 (Kaschube, Stelzer, Matthaeus, Frangakis): Optimization and acceleration of image processing algorithms
- Work package 1: Development of the toolbox
- Work package 2: Increasing the speed and reaching platform independence