Prof. Dr. Till Stephan

Professor for Super-resolution Microscopy of Living Cells

Institute of Molecular Biosciences, Goethe-University Frankfurt, Germany

 

Research Positions & Education

• Junior Professor (W1tt), Goethe-University Frankfurt, Germany
• Junior Research Group Leader, Goethe-University Frankfurt, Germany
• Postdoctoral fellow with Prof. Stefan Jakobs, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen, Germany

Honors and Awards

• Johanna Quandt Young Academy Fellow (2025)
• Emmy Noether Fellow (2025)
• Evident Image of the Year Award (2024)

Selected papers

• Chen J, Stephan T, Gaedke F, Liu T, Li Y, Schauss A, Chen P, Wulff V, Jakobs S, Jüngst C, Chen Z (2024) An aldehyde-crosslinking mitochondrial probe for STED imaging in fixed cells. Proc Natl Acad Sci USA 121, e2317703121. doi:10.1073/pnas.2317703121 
• Stephan T^*, Stoldt S^*, Barbot M^*, Carney TD, Lange F, Bates M, Bou Dib P, Inamdar K, Shcherbata HR, Meinecke M, Riedel D, Dennerlein S, Rehling P, Jakobs S (2024) Drosophila MIC10b can polymerize into cristae-shaping filaments. Life Sci Alliance 7, e202302177. doi:10.26508/lsa.202302177 (Front Cover Story in LSA 2024) 
• Ebrahimi V, Stephan T, Kim J, Carravilla P, Eggeling C, Jakobs S, Han KY (2023) Deep learning enables fast, gentle STED microscopy. Commun Biol 6, 674. doi:10.1038/s42003-023-05054-z
• Liu T^*, Stephan T^*, Chen P, Keller-Findeisen J, Chen J, Riedel D, Yang Z, Jakobs S, Chen Z (2022) Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain. Proc Natl Acad Sci USA 119, e2215799119. doi:10.1073/pnas.2215799119 (Front Cover Story in PNAS 2022)
• Bates M, Keller-Findeisen J, Przybylski A, Hüper A, Stephan T, Ilgen P, Cereceda Delgado AR, D’Este E, Egner A, Jakobs S, Sahl SJ, Hell SW (2022). Optimal precision and accuracy in 4Pi-STORM using dynamic spline PSF models. Nat Methods 19, 603–612. doi:10.1038/s41592-022-01465-8 
• Tameling C, Stoldt S, Stephan T, Naas J, Jakobs S, Munk A (2021) Colocalization for super-resolution microscopy via optimal transport. Nat Comput Sci 1, 199–211. doi:10.1038/s43588-021-00050-x (Front Cover Story and News & Views in Nature Computation Sciences 2021)
• Stephan T^*, Brüser C^*, Deckers M, Steyer AM, Balzarotti F, Barbot M, Behr TS, Heim G, Hübner W, Ilgen P, Lange F, Pacheu-Grau D, Pape JK, Stoldt S, Huser T, Hell SW, Möbius W, Rehling P, Riedel D, Jakobs S (2020) MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation. EMBOJ 39, e104105. doi:10.15252/embj.2019104105 (Front Cover Story and News & Views in EMBOJ 2020)
• Pape JK^*, Stephan T^*, Balzarotti F, Büchner R, Lange F, Riedel D, Jakobs S, Hell SW (2020) Multicolor 3D MINFLUX nanoscopy of mitochondrial MICOS proteins. Proc Natl Acad Sci USA 117, 20607–20614. doi:10.1073/pnas.2009364117 (Research Highlight in PNAS 2020)
• Stephan T, Rösch A, Riedel D, Jakobs S (2019) Live-cell STED nanoscopy of mitochondrial cristae. Sci Rep 9, 12419. doi:10.1038/s41598-019-48838-2 (Top100 Cell and Molecular Biology Publication in Sci Rep in 2019)
• Stoldt S^*, Stephan T^*, Jans DC, Brüser C, Lange F, Keller-Findeisen J, Riedel D, Hell SW, Jakobs S (2019) Mic60 exhibits a coordinated clustered distribution along and across yeast and mammalian mitochondria. Proc Natl Acad Sci USA 116, 9853. doi:10.1073/pnas.1820364116

   ^*equal contribution